ELK Biotechnology ICAD rabbit pAb
ICAD(DFFA) 단백질을 인식하는 토끼 다클론 항체로, apoptosis 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 실험에 사용 가능하며, 사람·마우스·랫트 시료에 반응합니다. -20°C에서 장기 보관이 가능합니다.
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ICAD rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | ICAD rabbit pAb |
| Alternative Names | DFFA; DFF1; DFF45; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DFFA (AA range: 151–200) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kDa |
| Gene ID (Human) | 1676 |
| Human Swiss-Prot No. | O00273 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of chromosomal DNA into nucleosomal units.
DNA fragmentation factor (DFF) is a heterodimeric protein composed of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis.
DFF becomes activated when DFFA is cleaved by caspase-3, causing the cleaved fragments of DFFA to dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
[Provided by RefSeq, Jul 2008]
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