ELK Biotechnology hnRNP A1 rabbit pAb
Human hnRNP A1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 핵과 세포질에서 발현되는 hnRNP A1 검출에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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ELK Biotechnology hnRNP A1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | hnRNP A1 rabbit pAb |
| Alternative Names | HNRNPA1; HNRPA1; Heterogeneous nuclear ribonucleoprotein A1; hnRNP A1; Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human hnRNP A1 (AA range: 51–100) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kD |
| Gene ID (Human) | 3178 |
| Human Swiss-Prot No | P09651 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Nucleus, Cytoplasm
- Localized in cytoplasmic mRNP granules containing untranslated mRNAs
- Shuttles continuously between the nucleus and cytoplasm along with mRNA
- Component of ribonucleosomes (PubMed:17289661)
- During microbial infection:
- Colocalizes with HCV NS5B at cytoplasmic speckles in an HCV-replication dependent manner
- SARS-CoV-2 ORF6 protein increases accumulation in the nucleus
Background
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport.
The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing.
Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20.
Multiple alternatively spliced transcript variants have been found.
There are numerous pseudogenes of this gene distributed throughout the genome.
(Provided by RefSeq, Feb 2016)
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