Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (GATA3/2444)
GATA-3 단백질을 인식하는 mouse monoclonal antibody로, 유방 및 요로상피 종양 마커 분석에 적합. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용 가능. 단백질 A/G 정제, 무보존제 PBS 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GATA3/2444 |
| Immunogen | Recombinant fragment of human GATA3 protein (around aa 357–436) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes. GATA3, an enhancer-binding protein containing a zinc finger domain, is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through enhancer binding. The human GATA3 gene comprises six exons distributed over 17 kb of DNA, with two zinc fingers encoded by separate exons conserved with those of GATA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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