Thermo Fisher Scientific DKC1 Polyclonal Antibody, MaxPab

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein sequence:

MADAEVIILP KKHKKKKERK SLPEEDVAEI QHAEEFLIKP ESKVAKLDTS QWPLLLKNFD KLNVRTTHYT PLACGSNPLK REIGDYIRTG FINLDKPSNP SSHEVVAWIR RILRVEKTGH SGTLDPKVTG CLIVCIERAT RLVKSQQSAG KEYVGIVRLH NAIEGGTQLS RALETLTGAL FQRPPLIAAV KRQLRVRTIY ESKMIEYDPE RRLGIFWVSC EAGTYIRTLC VHLGLLLGVG GQMQELRRVR SGVMSEKDHM VTMHDVLDAQ WLYDNHKDES YLRRVVYPLE KLLTSHKRLV MKDSAVNAIC YGAKIMLPGV LRYEDGIEVN QEIVVITTKG EAICMAIALM TTAVISTCDH GIVAKIKRVI MERDTYPRKW GLGPKASQKK LMIKQGLLDK HGKPTDSTPA TWKQEYVDYS ESAKKEVVAE VVKAPQVVAE AAKTAKRKRE SESESDETPP AAPQLIKKEK KKSKKDKKAK AGLESGAEPG DGDSDTTKKK KKKKKAKEVE LVSE

Target Information

The DKC1 gene belongs to the H/ACA snoRNPs gene family, which plays a crucial role in rRNA processing and modification. H/ACA snoRNPs include the NOLA1, NOLA2, and NOLA3 proteins, all of which localize to nucleoli and nuclear coiled bodies. Depletion of any of these proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex.

Mutations in the DKC1 gene are associated with X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome, both of which are disorders affecting skin, nails, and bone marrow function. The gene is transcribed in a telomere-to-centromere direction and has two transcript variants encoding different isoforms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.