Thermo Fisher Scientific DIO1 Monoclonal Antibody (1E4)
DIO1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody(1E4). ELISA에 최적화되어 있으며, 비결합형 액상 형태로 제공. -20°C에서 보관하며, 연구용으로만 사용 가능.
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Applications
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E4 |
| Immunogen | DIO1 (NP_000783.2, 35 a.a. ~125 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
DRVKRNILAM GEKTGMTRNP HFSHDNWIPT FFSTQYFWFV LKVRWQRLED
TTELGGLAPN CPVVRLSGQR CNIWEFMQGN RPLVLNFGSC TTarget Information
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) through outer ring deiodination (ORD) to bioactive 3,3’,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).
Alternative splicing results in multiple transcript variants encoding different isoforms. Some isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3’ UTR of Sec-containing genes has a common stem-loop structure (SECIS) necessary for UGA recognition as a Sec codon rather than a stop signal.
Additional transcript variants have been described but are not supported by experimental evidence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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