Thermo Fisher Scientific BST2 Polyclonal Antibody, Biotin
BST2 단백질을 인식하는 Biotin 표지 폴리클로날 항체로, Western blot, IHC, ICC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-epitope synthetic peptide within amino acid region 100–150 of human bone marrow stromal antigen 2 (BST2/CD317). |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol and 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BST2 (also known as CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in B-cell development and growth. Its expression on fibroblast cell lines supports stromal cell-dependent growth of pre-B-cell lines. BST2 is highly expressed in B-cell lineages, T-cells, monocytes, NK cells, dendritic cells, and myeloma cells.
Studies indicate that BST2 acts as an inhibitor of retrovirus release from human cells, with its activity counteracted by the HIV-1 accessory protein Vpu. BST2-mediated retention of virions on cell surfaces or endocytosis into BST2-positive compartments is abolished when BST2 is depleted, highlighting its potential as a therapeutic target in HIV/AIDS. Dysregulation of BST2 has also been associated with stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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