Thermo Fisher Scientific Bim Polyclonal Antibody
Bim 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 등 다양한 종에 반응. Western Blot 및 Immunoprecipitation에 적합하며 항원 친화 크로마토그래피로 정제. 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the amino terminus of human Bim |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 339 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981696 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
BIM belongs to the BCL-2 protein family. These family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. The encoded protein contains a Bcl-2 homology domain 3 (BH3) and interacts with other BCL-2 family members such as BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate it acts as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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