Thermo Fisher Scientific ITIH4 Polyclonal Antibody
Human ITIH4 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 정제 방식으로 제조되었으며, PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITIH4. Recombinant protein control fragment (Product #RP-100485) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642820 |
Product Specific Information
Immunogen sequence:
LAYSFVTPLT SMVVTKPDDQ EQSQVAEKPM EGESRNRNVH SAGAAGSRMN FRPGVLSSRQ LGLPGPPDVP DHAAYHPFRR LAILPASAPP ATSNPDPAVS RVMNMKIEET TMTTQTPA
Highest antigen sequence identity to the following orthologs:
- Mouse: 35%
- Rat: 36%
Target Information
The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and result from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays inhibitory activity against trypsin, leukocyte elastase, and plasmin. The heavy chains do not have protease inhibitory properties but can interact with hyaluronic acid, promoting extracellular matrix stability. The ITI protein family is suspected of playing a key role in extracellular matrix biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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