Thermo Fisher Scientific NFIB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL
• View 1 publication

Product Specifications

Product Specific Information

Immunogen sequence:
VKSGVFNVSE LVRVSRTPIT QGTGVNFPIG EIPSQPYYHD MNSGVNLQRS LSSPPSSKRP KTISIDENME PSPTGDFYPS PSSPAAGSRT WHERDQDMSS PTTMKKPEKP LFSSASPQDS SPRLSTFPQH HHPGIPGVAH SVISTRTP

Highest antigen sequence identity to the following orthologs:

• Mouse: 99%
• Rat: 99%

Target Information

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from alternate splicing of a single NF-1 gene.
NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain and activates transcription through a proline-rich, carboxy-terminal transactivation domain.
The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes.
The NF-1 consensus element has been found in the upstream promoter region of numerous eukaryotic genes, including Ha-Ras, alpha-globin, HSP70, GRP78, Histone H1, myelin basic protein, and Xenopus laevis vitellogenin gene promoter.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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