Thermo Fisher Scientific NFIB Polyclonal Antibody
Rabbit polyclonal antibody targeting human NFIB protein. Validated for WB and ICC/IF applications with high species reactivity (human). Purified by antigen affinity chromatography and supplied in PBS with 40% glycerol. Ideal for transcription factor re...
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NFIB. Recombinant protein control fragment (Product #RP-102298) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644645 |
Product Specific Information
Immunogen sequence:
VKSGVFNVSE LVRVSRTPIT QGTGVNFPIG EIPSQPYYHD MNSGVNLQRS LSSPPSSKRP KTISIDENME PSPTGDFYPS PSSPAAGSRT WHERDQDMSS PTTMKKPEKP LFSSASPQDS SPRLSTFPQH HHPGIPGVAH SVISTRTP
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from alternate splicing of a single NF-1 gene.
NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain and activates transcription through a proline-rich, carboxy-terminal transactivation domain.
The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes.
The NF-1 consensus element has been found in the upstream promoter region of numerous eukaryotic genes, including Ha-Ras, alpha-globin, HSP70, GRP78, Histone H1, myelin basic protein, and Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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