Thermo Fisher Scientific Human CDCA8 Synthetic Peptide

Thermo Fisher Scientific Human CDCA8 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the amino terminus of human CDCA8.
PEP-0696 can be used as a blocking peptide with polyclonal antibody PA5-20576.

Target Information

CDCA8 is a component of the chromosomal passenger complex (CPC), which includes Survivin, CDCA8, INCENP, and Aurora-B. This complex is essential for the stability of the bipolar mitotic spindle and plays crucial roles during mitosis and cell division.

CDCA8 interacts with Aurora-B, INCENP, and Survivin, showing increased expression during the G2/M phase and reduction after M phase exit. It is cell cycle-regulated, down-regulated by p53/Rb signaling, and up-regulated in various cancer tissues. In Drosophila, CDCA8 inactivation causes polyploidy, delayed mitosis, and abnormal tissue development, indicating its critical role in cell proliferation.

Recent studies demonstrate that CDCA8 is essential for early embryonic development, and its loss leads to embryonic lethality that cannot be rescued by p53 deletion. Aberrant expression of CDCA8 is associated with poor prognosis in gastric cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.