Thermo Fisher Scientific Phospho-LCK (Tyr192) Polyclonal Antibody
인간 LCK 단백질의 Tyr192 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
- 카탈로그번호
- 44844G
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-LCK (Tyr192) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Lck that contains tyrosine 192 (based on Swiss Protein database, accession number P06239). The sequence is conserved in mouse. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533778 |
Target Information
LCK is a member of the Src-family tyrosine kinases, essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates ITAM motifs in the zeta subunits, establishing binding sites for the SH2 domains of ZAP70, which is also phosphorylated by LCK to generate signaling platforms via LAT phosphorylation.
Most LCK is localized to the plasma membrane, with a fraction associated with the Golgi apparatus that may contribute to Raf activation under weak TCR stimulation.
LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2/SH3 domains for protein-protein interactions. It is also involved in apoptosis regulation induced by various stimuli, excluding death receptors.
Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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