Thermo Fisher Scientific Endothelin 3 Polyclonal Antibody
Rabbit polyclonal antibody against human Endothelin 3. Validated for Western blot at 1 µg/mL. Affinity purified and supplied in PBS with 2% sucrose. Suitable for research use in studying endothelin signaling and related disorders.
- 카탈로그번호
- PA545183
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested at 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human EDN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609425 |
Product Specific Information
- Peptide sequence: LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL
- Sequence homology: Human: 100%; Pig: 85%
Target Information
The protein encoded by this gene belongs to the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in various biological functions. The active form is a 21-amino-acid peptide processed from the precursor protein and acts as a ligand for endothelin receptor type B (EDNRB). Interaction with EDNRB is essential for the development of neural crest-derived lineages such as melanocytes and enteric neurons. Mutations in this gene and EDNRB are associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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