Thermo Fisher Scientific CD83 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: GTYRCTLQDP DGQRNLSGKV ILRVTGCPAQ RKEETFKKYR AEIVLLLALV
• Sequence homology: Human: 100%; Pig: 91%

Target Information

CD83 cell surface antigen is a 40–45 kDa glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express very low levels of CD83 after culture with agents such as Con A or PHA.

In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres. It is also expressed by Langerhans cells in the skin.

The CD83 antigen is a 186-amino-acid single-chain glycoprotein and a member of the immunoglobulin superfamily. It contains an extracellular V-type Ig-like domain, a transmembrane region, and a short 40-amino-acid cytoplasmic tail. CD83 undergoes extensive post-translational glycosylation, resulting in a molecular weight approximately twice that of the core protein.

CD83+ cells have a unique surface immunophenotype distinct from T cells, B cells, NK cells, or myelomonocytic lineage cells. They coexpress high levels of MHC class II molecules and markers from multiple lineages, including T cell (CD2, CD5), B cell (CD40, CD78), and myeloid (CD13, CD33, CD36) markers, as well as cytokine receptors.

Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.