Thermo Fisher Scientific KLF4 Polyclonal Antibody
KLF4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성 확인. 항원 친화 크로마토그래피로 정제, PBS/glycerol 버퍼에 보관. 줄기세포 연구 및 세포 분화 관련 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 1–212 of Human KLF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2544917 |
Product Specific Information
- Recommended positive control: HeLa cells
- Predicted reactivity: Mouse (89%), Rat (89%), Cat (93%), Pig (93%), Sheep (92%), Rhesus Monkey (98%), Bovine (92%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Kruppel-like factor 4 (KLF4) is encoded by the KLF4 gene located on chromosome 9 in humans.
Also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF), KLF4 belongs to the conserved Kruppel-like family of DNA-binding zinc finger transcription factors.
It plays a crucial role in cellular reprogramming as one of the Yamanaka factors, converting differentiated cells into pluripotent stem cells.
KLF4 is involved in endothelial signaling, adipogenesis, differentiation, embryogenesis, and cell cycle control.
Its localization determines functional significance — nuclear localization is associated with oncogenic activity, while cytosolic localization correlates with tumor suppression.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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