Thermo Fisher Scientific CD3e Monoclonal Antibody (UCHT1), Alexa Fluor 488
Alexa Fluor 488 형광 표지를 가진 CD3e 단클론 항체로, 인간 T 세포의 CD3 복합체를 검출하는 데 사용됩니다. Flow Cytometry에 적합하며, UCHT1 클론 기반으로 높은 특이성과 신뢰성을 제공합니다. 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UCHT1 |
| Immunogen | Human thymocytes followed by Sezary T cells |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 0.04 mg/mL |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient |
| RRID | AB_2633285 |
Additional Formats
- Alexa Fluor 405
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- FITC
- Pacific Blue
- Pacific Orange
- PE
- Qdot 605
- Custom conjugation upon request
Target Information
The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. CD3 subunits (gamma, delta, epsilon, zeta) are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11. These components associate with cytoplasmic signal transduction molecules via tyrosine-based motifs. CD3 plays roles in TCR-induced growth arrest, cell survival, and proliferation. It is expressed on 68–82% of normal peripheral blood lymphocytes and 65–85% of thymocytes, but not on B or NK cells. Altered T lymphocyte levels may be observed in autoimmune diseases. Defects in CD3 genes are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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