Thermo Fisher Scientific CD3e Monoclonal Antibody (UCHT1), Alexa Fluor 647

Applications

• Flow Cytometry (Flow): 5 µL / 1×10⁶ cells

Product Specifications

Additional Conjugate Formats

• Alexa Fluor 405
• Alexa Fluor 700
• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• Qdot 605
• Custom conjugation available

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into T cell cytoplasm and regulating TCR surface expression. Activation of T cells through the TCR involves CD3 gamma, delta, epsilon, and zeta subunits—members of the immunoglobulin superfamily encoded on chromosome 11.
These subunits contain cytoplasmic tails with tyrosine-based motifs that mediate signal transduction and may influence TCR-induced growth arrest, survival, and proliferation.
CD3 antigen is expressed on 68–82% of peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Reduced T lymphocyte percentages can occur in autoimmune diseases. Defects in CD3 genes are linked to CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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