Thermo Fisher Scientific RyR2 Polyclonal Antibody

Thermo Fisher Scientific RyR2 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
QDEVRGDGEE GERKPLEAAL PSEDLTDLKE LTEESDLLSD IFGLDLKREG GQYKLIPHNP NAGLSDLMSN PVPMPEVQEK FQEQKAKEEE KEEKEETKSE PE

Target Information

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop involved in interactions with RyR. Phosphorylation of the DHPR alpha1-subunit may also play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis. Cells lacking RyR also lack excitation-contraction coupling and exhibit a reduction in Ca²⁺ current density.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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