Thermo Fisher Scientific ARRDC1 Polyclonal Antibody
ARRDC1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 랫트 시료 반응성. 고순도 친화크로마토그래피 정제, PBS/glycerol 완충액에 보관. 연구용 전용 제품.
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- PA599589
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ARRDC1 (Accession Q8N5I2), corresponding to amino acid residues S389–S433 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818522 |
Product Specific Information
This antibody detects endogenous levels of total Arrdc1.
Target Information
ARRDC1 functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through a ubiquitination-dependent mechanism, it plays a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, it contributes to the extracellular transport of proteins between cells via the release of microvesicles (PubMed:22315426). By participating in ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, it negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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