Thermo Fisher Scientific PIP5K1C Polyclonal Antibody
Rabbit polyclonal antibody targeting Human PIP5K1C for Western blot applications. Recombinant fragment immunogen within amino acids 152–375. Unconjugated, liquid form, 0.49 mg/mL concentration. Suitable for multiple cell lines and species cross-reactiv...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 152–375 of Human PIP5K1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.49 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545750 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, mouse brain
- Predicted reactivity: Mouse (94%), Rat (94%), Chicken (95%), Bovine (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PIP5K1C lipid kinase (phosphatidylinositol-4-phosphate 5-kinase 1 gamma) phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate.
This protein is localized at synapses and plays roles in endocytosis and cell migration.
PIP5K1C associates with β-catenin, enhancing its activity downstream of growth factor stimulation.
Its expression and kinase activity promote β-catenin phosphorylation that facilitates nuclear import and transcriptional activation.
Deficiency of PIP5K1C impairs neutrophil recruitment due to adhesion defects, and it regulates adhesion via RhoA GTPase and integrin activation by chemoattractants.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm (California Proposition 65).
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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