Thermo Fisher Scientific Sodium Channel Pan Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: [References not provided]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100
• Publications: [References not provided]

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total sodium channel protein.

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow the flow of Na⁺ ions.
Nine NaV alpha subunits have been cloned and named NaV1.1–NaV1.9.
NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX):

• TTX-sensitive: NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6, NaV1.7
• TTX-resistant: NaV1.5, NaV1.8, NaV1.9

Mammalian sodium channels are heterotrimers composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific.
Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.