Thermo Fisher Scientific Catenin, beta (p120) Monoclonal Antibody (5H10)
Thermo Fisher Scientific의 Catenin, beta (p120) Monoclonal Antibody (5H10)은 Chicken, Human, Mouse에 반응하며 다양한 면역분석(WB, IHC, ICC, Flow)에 적합합니다. 단일클론 마우스 IgG1 항체로, Protein A/G 정제 및 PBS buffer에 보관됩니다. 세포 부착 및 신호전달 연구용에 최적화된 제품입니다.
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Thermo Fisher Scientific Catenin, beta (p120) Monoclonal Antibody (5H10)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Fusion protein consisting of the maltose binding protein fused to a 100 amino acid segment of the C-terminus of chicken beta-Catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the formation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. It also binds to cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, interacting with signaling pathways such as tyrosine kinases, phosphatases, and Wnt/Wingless. This interplay regulates morphogenesis and cell proliferation, influencing tumorigenesis in several cancers including colorectal, ovarian, and breast cancer. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that stimulate transcription of target genes such as cyclin D and c-myc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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