Thermo Fisher Scientific BTK Monoclonal Antibody (OTI15G8), TrueMAB
BTK 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry 등에 적합함. 인간 BTK 전체 길이 재조합 단백질로 면역화되었으며, 고순도 정제 및 안정적 액상 형태로 제공됨. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15G8 |
| Immunogen | Full-length human recombinant BTK protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily. Mutations in the BTK gene are associated with developmental blocks in human B-cell ontogeny and immunodeficiency disorders. BTK interacts with toll-like receptor (TLR) family members such as TLR4, 6, 8, and 9, which play essential roles in innate and adaptive immunity. It also interacts with proteins involved in TLR4 signaling, including MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting BTK’s involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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