Thermo Fisher Scientific DAXX Recombinant Rabbit Monoclonal Antibody (ARC2220)
DAXX 단백질을 인식하는 토끼 모노클로날 항체로, Western blot 및 ELISA에 적합합니다. 인간 시료에 반응하며, HEK293 세포에서 발현된 재조합 항체입니다. 고순도의 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2220 |
| Immunogen | Synthetic peptide corresponding to amino acids 200–300 of human Daxx (Q9UER7) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897865 |
Product Specific Information
- Positive Samples: K-562, SH-SY5Y
- Immunogen sequence:
AEIRRLQEKE LDLSELDDPD SAYLQEARLK RKLIRLFGRL CELKDCSSLT GRVIEQRIPY RGTRYPEVNR RIERLINKPG PDTFPDYGDV LRAVEKAAAR H
Target Information
This gene encodes a multifunctional protein that resides in both the nucleus and cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1.
In the nucleus, the encoded protein acts as a transcription repressor binding to sumoylated transcription factors, with repression relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
It also associates with centromeres during G2 phase and may regulate apoptosis in the cytoplasm. Subcellular localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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