Thermo Fisher Scientific CD100 (Semaphorin-4D) Monoclonal Antibody (133-1C6)
CD100 (Semaphorin-4D) 단클론 항체로 인간 및 비인간 영장류 반응성. ICC/IF 및 유세포분석에 사용 가능. 비결합형 액상 형태, Protein A/G 정제. B세포 생존 및 신호 조절 연구에 적합. 연구용 전용 시약.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 133-1C6 |
| Immunogen | PHA stimulated human peripheral blood lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Horse
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as Semaphorin-4D) is a 150 kDa homodimer that induces B cell aggregation and enhances viability in vitro.
It modulates CD40–CD40L B cell signaling by promoting aggregation and survival while downregulating CD23 expression.
CD72 acts as a lymphocyte receptor for CD100, regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and more strongly on activated T and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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