Thermo Fisher Scientific OXER1 Polyclonal Antibody
Rabbit polyclonal antibody against human OXER1 (TG1019) for IHC (paraffin) applications. Detects GPCR TG1019 with high specificity. Supplied as liquid at 1 mg/mL. Store at 4°C short term or -20°C long term. For research use only.
- 카탈로그번호
- PA132732
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested at 30 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from the C-terminus of human TG1019 (OXER1, UniProt ID: Q8TDS5-1, antigen length: 423 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2299012 |
Product Specific Information
PA1-32732 detects GPCR TG1019 from human samples.
Target Information
TG1019 (OXER1) is a G protein-coupled receptor that acts as a chemoattractant for eosinophils and neutrophils. It is expressed in multiple tissues except the brain, with highest levels in liver, kidney, peripheral leukocytes, lung, and spleen.
TG1019 interacts with the OXE protein to form a Galpha i/o-coupled receptor complex that signals through PLC/calcium, MEK/ERK, and PI3K/Akt pathways. Upon stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE), TG1019 induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt signaling. It may also play a role in downregulating cAMP production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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