Thermo Fisher Scientific RASA1 Monoclonal Antibody (OTI1A4), TrueMAB

Applications

• Western Blot (WB): 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TACC1 is located on the 8p11 chromosomal region, which is amplified in approximately 15% of breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancer tumors.
TACC family members (TACC1, TACC2, TACC3) are closely mapped to FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10, respectively.
Since they are phylogenetically related, TACC and FGFR are proposed to have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.