Thermo Fisher Scientific SHOX Polyclonal Antibody

Thermo Fisher Scientific SHOX Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GTSDSSLQDIT EGGGHCPVHL FKDHVDNDKE KLKEFGTARV AEGIYECKEK REDVK

Highest antigen sequence identity to the following orthologs:

• Mouse: 27%
• Rat: 30%

Target Information

Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation, and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind a site in the regulatory region of the target gene.

SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes splicing resulting in two isoforms, SHOXA and SHOXB.

• SHOXA: Expressed in skeletal muscle, placenta, pancreas, heart, and bone marrow fibroblast; lesser extent in kidney and lung.
• SHOXB: Highly expressed in osteogenic cells; not expressed in brain, kidney, liver, or lung.

Defects in the gene SHOX cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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