Thermo Fisher Scientific ACVR2A Monoclonal Antibody (149/1)

Thermo Fisher Scientific ACVR2A Monoclonal Antibody (149/1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-91751 detects Activin receptor type II from human samples.

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII

These receptors are transmembrane proteins composed of:

• A ligand-binding extracellular domain with cysteine-rich region
• A transmembrane domain
• A cytoplasmic domain with predicted serine/threonine specificity

Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
After ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.