Thermo Fisher Scientific Spectrin alpha-1 Monoclonal Antibody (17C7)

Thermo Fisher Scientific Spectrin alpha-1 Monoclonal Antibody (17C7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-91738 detects alpha 1 Spectrin from mouse, rat, and human samples.
It has been successfully used in immunofluorescence, immunohistochemistry (frozen tissue), and Western blot applications.
The immunogen is recombinant alpha I spectrin (erythroid spectrin) SH3 domain.

Target Information

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton. It functions in determining cell shape, arrangement of transmembrane proteins, and organization of organelles.
Spectrin is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. The encoded protein contains 22 spectrin repeats involved in dimer formation and forms weaker tetramer interactions than non-erythrocytic alpha spectrin, increasing plasma membrane elasticity and deformability of red blood cells.
Mutations in this gene are associated with hereditary red blood cell disorders such as elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
(Information provided by RefSeq, Jul 2008)

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.