Thermo Fisher Scientific Spectrin alpha-1 Monoclonal Antibody (17C7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

-

Immunohistochemistry (Frozen) (IHC (F))

1:10-1:50

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

ELISA (ELISA)

1:100,000-1:1,000,000

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

17C7

Immunogen

Recombinant alpha I spectrin (erythroid spectrin) SH3 domain.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2194331

Product Specific Information

MA1-91738 detects alpha 1 Spectrin from mouse, rat, human samples.

MA1-91738 has been successfully used in immunofluorescence, immunohistochemistry (frozen tissue), Western blot applications.

The MA1-91738 immunogen is: Recombinant alpha I spectrin (erythroid spectrin) SH3 domain.

Target Information

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.