Thermo Fisher Scientific HAP1 Monoclonal Antibody (1B6)
HAP1 단백질 검출용 Mouse monoclonal antibody (Clone 1B6). Western blot, IHC, ICC, Flow Cytometry, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein G 정제, PBS/glycerol buffer 보존. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.5–1.0 µg/mL | View 1 publication |
| Immunohistochemistry (Frozen) (IHC-F) | 0.5–1.0 µg/mL | — |
| Immunocytochemistry (ICC/IF) | Assay-dependent | — |
| Flow Cytometry (Flow) | 1 µg per million cells | — |
| Immunoprecipitation (IP) | 1:10–1:500 | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B6 |
| Immunogen | Fusion protein from rat HAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2232841 |
Product Specific Information
- In Western blot, bands can be seen at approximately 95 kDa for isoform A and 110 kDa for isoform B.
- Suggested positive control: rat brain.
Target Information
Huntington’s disease (HD) is a neurodegenerative disorder characterized by loss of striatal neurons, caused by an expansion of a polyglutamine tract in the huntingtin protein. HAP1 (Huntingtin-associated protein 1) was identified through two-hybrid library screening; its binding to huntingtin correlates with polyglutamine tract expansion.
HAP1 interacts with cytoskeletal proteins such as dynactin and pericentriolar autoantigen protein 1, indicating a role in vesicular trafficking or organelle transport. It is also involved in huntingtin-enhanced BDNF transport along microtubules. Impaired function of this process leads to reduced neurotrophic support and neuronal toxicity, potentially contributing to disease pathogenesis.
Several alternatively spliced isoforms of HAP1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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