Thermo Fisher Scientific MICA Polyclonal Antibody
인간 MICA 단백질에 특이적인 Rabbit Polyclonal Antibody로 다양한 응용(WB, IHC, ICC, Flow)에 사용 가능. 고순도 Protein A 및 Antigen affinity chromatography로 정제됨. 항종양 면역 반응 연구에 적합. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:25 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:25 | View 1 publication |
| Flow Cytometry (Flow) | 1:10–1:25 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 68–97 amino acids from the central region of human MICA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552656 |
Target Information
Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells.
A related family, termed the MHC class I chain-related (MIC) proteins, are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity.
MICA, a member of the MIC family, is widely expressed on many tumors, and the MICA/NKG2D interaction is thought to stimulate anti-tumor reactivity by T lymphocytes.
Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may be one component of the anti-tumor activity of the immune system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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