Thermo Fisher Scientific IREB2 Monoclonal Antibody (9D1)
IREB2 단백질을 인식하는 Mouse monoclonal antibody (Clone 9D1). Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며, Protein G로 정제된 액상형 제품. 철 대사 조절 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9D1 |
| Immunogen | Recombinant protein within human IREB2 aa 1–963 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2911670 |
Product Specific Information
- Positive Control: Jurkat cell lysate, Daudi cell lysate, human liver tissue lysate, human placenta tissue
- Subcellular Location: Cytoplasm
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia plays a role in normal tissue physiology and several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also functions during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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