Thermo Fisher Scientific P-Selectin Recombinant Rabbit Monoclonal Antibody (001)

Applications

Tested Application

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Additional Formats

• HRP Conjugate
• Request Custom Conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone antibody DNA sequences from immunoreactive rabbits, and individual clones are screened for optimal performance.

Advantages of recombinant rabbit monoclonal antibodies:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin–free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

This antibody specifically recognizes Mouse P-Selectin/CD62P/SELP.

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.

P-selectin mediates adhesion between activated endothelial cells or platelets and leukocytes. It binds sialylated Lewis blood group carbohydrate antigens on neutrophils and monocytes in a calcium-dependent manner. P-selectin expression is associated with inflammation, atherogenesis, thrombosis, and tissue injury, and is used clinically to differentiate heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.