Thermo Fisher Scientific Phospho-PPAR alpha (Ser21) Polyclonal Antibody
PPAR alpha의 Ser21 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 ICC/IF에 사용 가능. 사람, 생쥐, 랫트 반응성. 고순도 정제 및 안정적 액상 형태로 연구용 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPARA (Accession Q07869), corresponding to amino acid residues around phosphorylated Ser21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817193 |
Product Specific Information
This antibody detects endogenous levels of PPAR alpha only when phosphorylated at Ser21.
Target Information
Peroxisome proliferators are non-genotoxic carcinogens that exert their effects via nuclear hormone receptors called peroxisome proliferator activated receptors (PPARs). These ligand-dependent intracellular proteins stimulate transcription of specific genes by binding to DNA sequences after activation. PPARs are activated by compounds such as clofibric acid, nafenopin, WY-14,643, and certain fatty acids. They can induce transcription of acyl CoA oxidase and cytochrome P450 (CYP450) A6 through specific response elements. PPARs also heterodimerize with retinoid X receptor (RXR) alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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