Thermo Fisher Scientific DCP Polyclonal Antibody
DCP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합. Hepatocellular carcinoma 연구용으로 사용되며, 고순도 Protein A 정제 및 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human DCP, amino acids 31–130 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as des-γ-carboxy prothrombin (DCP), is an abnormal form of prothrombin produced primarily by liver tissues under conditions of vitamin K deficiency or antagonism. This immature prothrombin variant lacks sufficient coagulation activity and is prominently overexpressed in hepatocellular carcinoma (HCC) cells, serving as a crucial biomarker for screening and diagnosing HCC. PIVKA-II also appears in some cases of gastric cancer, albeit less frequently. Elevated serum levels of PIVKA-II are not exclusive to malignancies; they can also be seen in non-HCC conditions, which necessitates differential diagnostic strategies. The utility of PIVKA-II is further underscored by its ability to predict extrahepatic metastases in early HCC, supporting its role in comprehensive patient evaluation and monitoring.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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