Thermo Fisher Scientific DCP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

Flow Cytometry (Flow)

1:20-1:100

-

ELISA (ELISA)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human DCP, amino acids 31-130. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DCP,uniProtId:P00734-1,ncbiNodeId:9606,antigenRange:31-130,antigenLength:622,antigenImageFileName:BS-1037R_DCP_P00734-1_Rabbit.svg,antigenImageFileNamePDP:BS-1037R_DCP_P00734-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as des-?-carboxy prothrombin (DCP), is an abnormal form of prothrombin produced primarily by liver tissues under conditions of vitamin K deficiency or antagonism. This immature prothrombin variant lacks sufficient coagulation activity and is prominently overexpressed in hepatocellular carcinoma (HCC) cells, serving as a crucial biomarker for screening and diagnosing HCC. PIVKA-II also appears in some cases of gastric cancer, albeit less frequently. Elevated serum levels of PIVKA-II are not exclusive to malignancies; they can also be seen in non-HCC conditions, which necessitates differential diagnostic strategies. The utility of PIVKA-II is further underscored by its ability to predict extrahepatic metastases in early HCC, supporting its role in comprehensive patient evaluation and monitoring.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.