Thermo Fisher Scientific Phospho-Syk (Tyr348) Polyclonal Antibody
SYK 단백질의 Tyr348 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 1 mg/mL 농도의 액상 제품이며, -20°C에서 보관합니다. 알레르기 및 자가면역 연구에 활용 가능합니다.
- 카탈로그번호
- PA538094
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human SYK around the phosphorylation site of Tyr348 (E-V-YP-E-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554697 |
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcepsilonRI) triggering, phosphorylating downstream adaptor proteins to initiate signaling pathways such as calcium mobilization, cytoskeleton remodeling, and transcription of specific genes.
Syk binds to receptor assemblies via its SH2 domains interacting with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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