Thermo Fisher Scientific Phospho-STAT5 beta (Ser731) Polyclonal Antibody
STAT5B 인산화 부위(Ser731)를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 검증 완료. 비결합형 액상 형태이며 농도 1 mg/mL. 세포 신호전달 및 STAT5 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human STAT5B around the phosphorylation site of Ser731 (A-P-SP-P-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554696 |
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the cell nucleus, where they act as transcription activators.
This protein mediates signal transduction triggered by various ligands such as IL2, IL4, CSF1, and growth hormones. It is involved in diverse biological processes including TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.
This gene was found to fuse with the retinoic acid receptor-alpha (RARA) gene in a subset of acute promyelocytic leukemias (APLL). Dysregulation of signaling pathways mediated by this protein may contribute to APLL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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