Thermo Fisher Scientific LRP6 Monoclonal Antibody (290913)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

290913

Immunogen

CHO-derived recombinant mouse LRP-6 Met1-Pro1368 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRP6,uniProtId:O88572-1,ncbiNodeId:10090,antigenRange:1-1368,antigenLength:1613,antigenImageFileName:MA5-23995_LRP6_O88572-1_Rat.svg,antigenImageFileNamePDP:MA5-23995_LRP6_O88572-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609984

Product Specific Information

In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombinant human (rh) LRP-6 and no cross-reactivity with rhLDL R.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.