Thermo Fisher Scientific CCDC106 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CCDC106. Recombinant protein control fragment (Product #RP-99160). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CCDC106,uniProtId:Q9BWC9-1,ncbiNodeId:9606,antigenRange:1-92,antigenLength:280,antigenImageFileName:PA5-59790_CCDC106_Q9BWC9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59790_CCDC106_Q9BWC9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639356

Product Specific Information

Immunogen sequence: MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQ

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 90%.

Target Information

The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.