Thermo Fisher Scientific PTEN Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee.

Target Information

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.
The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to dual-specificity protein tyrosine phosphatases.
Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates.
It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate and functions as a tumor suppressor by inhibiting the AKT/PKB signaling pathway.
PTEN plays a key role in modulating the AKT-mTOR signaling pathway, influencing neuron positioning, dendritic development, and synapse formation during adult neurogenesis.
Additionally, PTEN may act as a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form exhibits higher apoptotic potential, whereas the cytoplasmic nonubiquitinated form shows less tumor suppressive ability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: IHC-00358_PTEN_P60484-1_Rabbit.svg, IHC-00358_PTEN_P60484-1_Rabbit_PDP.jpeg)