Thermo Fisher Scientific IRS1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rabbit, Pig, Gorilla, Chimpanzee, and Naked mole rat

Target Information

IRS-1 is a major substrate of the insulin receptor and is phosphorylated in response to stimulation by insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4). It undergoes phosphorylation on serine, threonine, and tyrosine residues in various tissues. Casein kinase II mediates a portion of insulin-stimulated serine/threonine phosphorylation of IRS-1 in vivo, with Thr 502 identified as the major phosphorylation site and Ser 99 as an additional site. IRS-1 contains three putative binding sites for 14-3-3 proteins (Ser 270, Ser 374, and Ser 641), with the motif around Ser 270 located in the phosphotyrosine binding domain responsible for interaction with the insulin receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)