Thermo Fisher Scientific ADRA1A Polyclonal Antibody
ADRA1A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Alpha-1A adrenergic receptor (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind endogenous catecholamines epinephrine and norepinephrine.
Nine receptor subtypes have been identified, including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3).
ARs are involved in various physiological and pathological processes such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence.
Alpha-1A adrenergic receptor (A1AR) subtypes are expressed in multiple tissues and are associated with regulation of blood pressure, vascular tone, and cardiac output.
A1AR activation also influences uterine contraction, hepatic glucose metabolism, expression of heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis.
Additionally, norepinephrine activation of alpha-1 AR in the hypothalamus may increase nitric oxide synthase (NOS) levels, potentially affecting hormone release such as LH, androgens, estrogen, and progesterone.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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