Thermo Fisher Scientific MCHR2 Polyclonal Antibody
MCHR2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 사용 가능. Human 시료 반응성. Affinity chromatography로 정제된 1 mg/mL 액상 제품이며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MCHR2 (Accession Q969V1), corresponding to amino acid residues S299–F340 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851528 |
Product Specific Information
Antibody detects endogenous levels of total MCHR2.
Target Information
Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal, and reproductive function in mammals by controlling the release of luteinizing hormone (LH).
The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45–50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several brain regions, including the cerebral cortex, amygdala, thalamus, and hypothalamus.
MCH and MCHR are also implicated in stimulating leptin expression and secretion in adipocytes, suggesting that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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