Thermo Fisher Scientific Nesprin 1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA VGLSGDHSAL ESQIRQLGKA LDDSRFQIQQ TENIIRSKTP TGPELDTSYK GYMKLLGECS SSIDSVKRLE HKLKEEEESL PGFVNLHSTE TQTAGVIDRW EL

Target Information

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.
These proteins are called nesprin-1 and nesprin-2 (nuclear envelope spectrin repeat proteins), characterized by multiple clustered spectrin repeats, bipartite nuclear localization sequences, and a conserved C-terminal transmembrane domain.
Transient transfection of EGFP-fusion constructs demonstrated localization to the nuclear membrane, with the C-terminal TM-domain essential for perinuclear localization.
Nesprin-1 is developmentally regulated in smooth and skeletal muscle and relocates during C2Cl2 myoblast differentiation. Nesprins may function as “dystrophins of the nucleus” to maintain nuclear organization and structural integrity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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