Thermo Fisher Scientific Scavenger Receptor BII Polyclonal Antibody
Scavenger Receptor BII에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제 및 1 mg/mL 농도의 액상 형태. -20°C 보관. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Scavenger Receptor BII (amino acids 181–280) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
High-density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk of atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene and are identical except for the encoded C-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediate selective uptake of HDL cholesteryl ester, but SR-BII has approximately fourfold lower efficiency than SR-BI. These receptors are expressed primarily in liver and non-placental steroidogenic tissues. SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, and both isoforms mediate selective lipid transfer between HDL and cells, potentially regulating lipid exchange dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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