Thermo Fisher Scientific DAPK1 Polyclonal Antibody
DAPK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(PFA 고정)에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. 세포 사멸 및 자가포식 관련 연구에 유용합니다.
- 카탈로그번호
- PA5115092
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DAPK1 (Accession P53355), corresponding to amino acid residues L284–D334. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899728 |
Product Specific Information
Antibody detects endogenous levels of total DAPK1.
Target Information
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon-induced programmed cell death and is a potential tumor suppressor.
It participates in multiple cellular signaling pathways that regulate cell survival, apoptosis, and autophagy.
DAPK1 mediates both type I apoptotic (caspase-dependent) and type II autophagic (caspase-independent) cell death.
It phosphorylates PIN1, inhibiting its catalytic activity and nuclear localization, and also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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