Thermo Fisher Scientific DARC Polyclonal Antibody
DARC 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity chromatography 정제 및 안정한 PBS/glycerol buffer로 제공됩니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ACKR1 (Accession Q16570), corresponding to amino acid residues M1–P37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899730 |
Product Specific Information
This antibody detects endogenous levels of total DARC.
Target Information
ACKR1 (also known as DARC) is an atypical chemokine receptor that regulates chemokine levels and localization through high-affinity binding. Unlike classical receptors, it does not trigger signal transduction but mediates chemokine sequestration, degradation, or transcytosis.
ACKR1 interacts with inflammatory chemokines from both CXC and CC subfamilies, but not with homeostatic chemokines. It also serves as a receptor for chemokines such as CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC, and for malaria parasites P. vivax and P. knowlesi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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