Thermo Fisher Scientific MTCO1 Polyclonal Antibody
MTCO1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 인간 및 마우스에 반응하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | View 6 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:25 | View publications |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 195–224 amino acids of human COXI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544188 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, mouse, porcine, rat, rabbit, Xenopus, and zebrafish based on sequence homology.
Target Information
Cytochrome c oxidase subunit I (CO1 or MTCO1) is one of three mitochondrial DNA (mtDNA)-encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV, located in the mitochondrial inner membrane, is the final enzyme of the electron transport chain in oxidative phosphorylation.
It consists of 13 polypeptides: subunits I–III are mtDNA-encoded, while subunits IV–VIII are nuclear-encoded. The enzyme complex contains four redox centers—two hemes (a, a3) and two copper centers (CuA, CuB)—with the hemes and CuB bound to subunit I. Studies have shown that mutations in the COX subunit I gene can affect enzyme function and mitochondrial respiration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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