Thermo Fisher Scientific CDT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–2 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
PATPPATPPA ASPSALKGVS QDLLERIRAK EAQKQLAQMT RCPEQEQRLQ

Sequence homology:
Cow: 93%
Dog: 77%
Human: 100%
Mouse: 100%
Pig: 100%
Rabbit: 93%
Rat: 100%
Yeast: 85%

Target Information

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself and requires other components of the MLL1/MLL complex for full activity. It has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.