Thermo Fisher Scientific PRDM2 Monoclonal Antibody (33AT1045)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

ChIP assay (ChIP)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

This antibody is specific for RIZ1 and does not recognize the beta isoform (RIZ2).

Target Information

PRDM2, a member of the nuclear/histone methyltransferase superfamily, contains:

• N-terminal PR domain
• Rb-binding motif
• 8 Kruppel-like zinc finger motifs
• Nuclear hormone-receptor binding motif
• C-terminal PR-domain binding motif

PRDM2 is expressed ubiquitously at low levels and exists in two isoforms:

• RIZ1 (280 kDa): Contains PR-domain
• RIZ2 (250 kDa): Truncated isoform lacking PR-domain

PRDM2 acts as a tumor suppressor involved in cell growth and differentiation. It binds to Retinoblastoma protein, estrogen receptor, GATA-3, and TPA-responsive element (MTE) of the Heme-oxygenase-1 gene. It plays a role in:

• Pathogenesis of Retinoblastoma
• Transcriptional regulation during neuronal differentiation
• Transactivation of Heme-oxygenase-1 gene
• Estrogen action mediation

Alterations or inactivation of PRDM2 due to mutations and hypermethylation occur in many types of human cancers, suggesting its potential as a biomarker.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)