Thermo Fisher Scientific PRDM2 Monoclonal Antibody (33AT1045)
PRDM2 단백질을 인식하는 Mouse IgG1 단클론 항체로, RIZ1 isoform에 특이적입니다. Western blot 및 ChIP assay에 적합하며, Protein G 정제된 액상 형태로 제공됩니다. 인간 및 생쥐 시료에 반응하며, 암 연구 및 세포 분화 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
ChIP assay (ChIP)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 33AT1045 |
| Immunogen | Purified recombinant GST fusion protein encoding aa 1–347 of human RIZ1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2170140 |
Product Specific Information
This antibody is specific for RIZ1 and does not recognize the beta isoform (RIZ2).
Target Information
PRDM2, a member of the nuclear/histone methyltransferase superfamily, contains:
- N-terminal PR domain
- Rb-binding motif
- 8 Kruppel-like zinc finger motifs
- Nuclear hormone-receptor binding motif
- C-terminal PR-domain binding motif
PRDM2 is expressed ubiquitously at low levels and exists in two isoforms:
- RIZ1 (280 kDa): Contains PR-domain
- RIZ2 (250 kDa): Truncated isoform lacking PR-domain
PRDM2 acts as a tumor suppressor involved in cell growth and differentiation. It binds to Retinoblastoma protein, estrogen receptor, GATA-3, and TPA-responsive element (MTE) of the Heme-oxygenase-1 gene. It plays a role in:
- Pathogenesis of Retinoblastoma
- Transcriptional regulation during neuronal differentiation
- Transactivation of Heme-oxygenase-1 gene
- Estrogen action mediation
Alterations or inactivation of PRDM2 due to mutations and hypermethylation occur in many types of human cancers, suggesting its potential as a biomarker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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